Therapeutic resistance: The Polyaneuploid cancer cell state enables resistance through endocycling:
Kim CJ, Gonye AL, Truskowski K, Lee CF, Cho YK, Austin RH, Pienta KJ, Amend SR. Nuclear morphology predicts cell survival to cisplatin chemotherapy. Neoplasia. 2023 Aug;42:100906. doi: 10.1016/j.neo.2023.100906. Epub 2023 May 10. PMID: 37172462; PMCID: PMC10314150.
Carroll C, Manaprasertsak A, Boffelli Castro A, van den Bos H, Spierings DCJ, Wardenaar R, Bukkuri A, Engström N, Baratchart E, Yang M, Biloglav A, Cornwallis CK, Johansson B, Hagerling C, Arsenian-Henriksson M, Paulsson K, Amend SR, Mohlin S, Foijer F, McIntyre A, Pienta KJ, Hammarlund EU. Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation. Cancer Res Commun. 2024 Mar 7;4(3):691-705. doi: 10.1158/2767-9764.CRC-23-0396. PMID: 38385626; PMCID: PMC10919208.
Kostecka LG, Mendez S, Li M, Khare P, Zhang C, Le A, Amend SR, Pienta KJ. Cancer cells employ lipid droplets to survive toxic stress. Prostate. 2024 May;84(7):644-655. doi: 10.1002/pros.24680. Epub 2024 Feb 26. PMID: 38409853.
Metastasis: The Polyaneuploid cancer cell state enables metastasis:
Mallin MM, Kim N, Choudhury MI, Lee SJ, An SS, Sun SX, Konstantopoulos K, Pienta KJ, Amend SR. Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential. Clin Exp Metastasis. 2023 Aug;40(4):321-338. doi: 10.1007/s10585-023-10216-8. Epub 2023 Jun 16. PMID: 37326720; PMCID: PMC10338627.
Mallin MM, Rolle LTA, Pienta KJ, Amend SR. Multiparameter flow cytometric detection and analysis of rare cells in in vivo models of cancer metastasis. Biol Methods Protoc. 2024 Apr 27;9(1):bpae026. doi: 10.1093/biomethods/bpae026. PMID: 38737789; PMCID: PMC11088742.
Eco-evolutionary models of cancer:
Brown JS, Amend SR, Austin RH, Gatenby RA, Hammarlund EU, Pienta KJ. Updating the Definition of Cancer. Mol Cancer Res. 2023 Nov 1;21(11):1142-1147. doi: 10.1158/1541-7786.MCR-23-0411. PMID: 37409952; PMCID: PMC10618731.
Butler G, Amend SR, Axelrod R, Venditti C, Pienta KJ. Punctuational evolution is pervasive in distal site metastatic colonization. bioRxiv [Preprint]. 2024 Apr 11:2024.04.08.588529. doi: 10.1101/2024.04.08.588529. PMID: 38645078; PMCID: PMC11030309.
Bukkuri A, Pienta KJ, Amend SR, Austin RH, Hammarlund EU, Brown JS. The contribution of evolvability to the eco-evolutionary dynamics of competing species. Ecol Evol. 2023 Oct 11;13(10):e10591. doi: 10.1002/ece3.10591. PMID: 37829179; PMCID: PMC10565728.